Form Wide Hotkeys

For the form, make sure to set this.KeyPreview = true;

Then you can define form-wide hotkeys like so...

private void frmMain_KeyDown(object sender, KeyEventArgs e)
{
    e.Handled = false;
    e.SuppressKeyPress = false;
    //F5,  Ctrl+E, Alt+X  .... all Execute! (just like query analyzer)
    if ((e.KeyCode == Keys.F5 && !e.Shift)
        || (e.KeyCode == Keys.E && e.Control)
        || (e.KeyCode == Keys.X && e.Alt))
    {
        e.Handled = true;
        e.SuppressKeyPress = true;
        Execute();
        return;
    }

    if (e.KeyCode == Keys.F5 && e.Shift)
    {
        e.Handled = true;
        e.SuppressKeyPress = true;
        Cancel();
        return;
    }
}